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Yankees vs Red Sox Betting Preview, Odds and Expert Prediction

Expert handicapper analysis of Yankees vs Red Sox with odds, matchup breakdown, and final score prediction.

(Photo by Getty Images) Giancarlo Stanton
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Boston (68-59) at NY Yankees (69-57)

  • When: Aug 21 2025, 7:15 PM
  • Where: Yankee Stadium, Bronx
  • Where to watch: FOX

Red Sox vs Yankees – Game Preview, Prediction and Player Props

Moneyline: NY Yankees -149
Total: 8.0
RunLine: NY Yankees -1.5 (+151)

New York Yankees Betting Outlook

The Yankees come in as -149 moneyline favorites, with the total set at 8.0 runs. After a brutal midseason slide, New York seems to have rediscovered its swagger. They return home riding a five-game winning streak, capped by a dramatic extra-inning victory over Tampa Bay. Giancarlo Stanton, Trent Grisham, and Austin Wells have all been supplying timely power, with the Bronx Bombers belting 14 homers over their last two games.

On the mound, Luis Gil (1-1, 5.14 ERA) gets the start. The young right-hander has shown steady improvement since returning from injury, giving up just one run in his last outing. Historically, Gil has dominated Boston, posting a 1.10 ERA in three career starts against them.

Yankees Prop Pick: Giancarlo Stanton to Hit a Home Run — Stanton thrives in rivalry games, and his swing looks locked in after his clutch blast in Tampa.

Boston Red Sox Betting Outlook

Boston, meanwhile, is trying to halt a skid. After going 21-6 in July and early August, the Sox have cooled off, dropping eight of their last 12. The offense has been the biggest culprit, they’ve gone just 3-for-28 with runners in scoring position across their last three games, repeatedly leaving opportunities on the table.

Lucas Giolito (8-2, 3.63 ERA) will try to stop the bleeding. He’s been sharp in August, logging a 2.84 ERA across three starts, though his career track record against the Yankees is shakier (4.85 ERA in five games). If Boston’s lineup can rediscover clutch hitting, they have the pitching to keep things tight.

Red Sox Prop Pick: Lucas Giolito Over 5.5 Strikeouts — Giolito has been sharp in August and will need to carry Boston. With New York’s power-heavy lineup, strikeouts are always in play, giving this prop strong value

MLB Prediction & Betting Angle

This is a classic rivalry with playoff positioning on the line. The Yankees’ power surge and Gil’s success against Boston tilt the matchup in New York’s favor. Boston should compete, but their RISP struggles remain a red flag for bettors.

Final Score Prediction: Yankees 5, Red Sox 3
Lean: NY Yankees -1.5 (+151)
Total: 
Under 8.5 Alt Lines (-125) 

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