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Brewers vs Diamondbacks Prediction & Odds: Betting Preview

Brewers favored vs Diamondbacks. Expert odds, matchup breakdown and score prediction for Thursday’s series finale

(Photo by Getty Images) Jose Quintana
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Arizona (65-69) at Milwaukee (83-51)

  • When: Aug 28 2025, 2:10 PM
  • Where: American Family Field, Milwaukee
  • Where to watch: FDSWI

Diamondbacks vs. Brewers – Game Betting Preview & Prediction

Moneyline: Milwaukee -164 
Spread: Milwaukee -1.5 (+125)
Total: 8.5

Milwaukee Brewers Betting Preview

Milwaukee enters Thursday’s series finale as the -164 moneyline favorite with the total sitting at 8.5 runs. After taking the first two games against Arizona, the Brewers slipped in Game 3 with a frustrating 1-for-12 performance with runners in scoring position during a 3-2 loss. Even so, Milwaukee still has a chance to secure the series win.

William Contreras has been a bright spot, homering in back-to-back games, while manager Pat Murphy praised the team’s aggressive approach on the bases despite a costly out late in Wednesday’s contest. The bigger concern for bettors is the bullpen, with closer Trevor Megill (30 saves, 2.54 ERA) hitting the injured list. That leaves Abner Uribe or Shelby Miller as possible ninth-inning options.

On the mound, Jose Quintana (10-4, 3.32 ERA) takes the ball. The veteran lefty has been consistent in August, posting a 2.83 ERA across 28 2/3 innings, though his career numbers against Arizona (1-2, 6.13 ERA) suggest some vulnerability.

Arizona Diamondbacks Betting Preview

Arizona enters this game aiming for a series split after Blaze Alexander’s two-run homer lifted them to victory Wednesday. Despite his recent slump (1-for-15 over his last four games), Alexander continues to earn praise from manager Torey Lovullo for his maturity and ability to slow the game down.

The D-backs will start Nabil Crismatt (1-0, 1.00 ERA), who has pitched well in limited opportunities this season. He last worked four scoreless innings in relief against Cincinnati, but his career history against Milwaukee (4.82 ERA in six appearances) hasn’t been kind. If he can navigate the early innings, Arizona’s offense, though inconsistent, has proven it can capitalize on mistakes.

MLB Betting Outlook & Prediction

The Brewers are the more complete team and have been dominant at home, but Megill’s absence at the back of the bullpen is notable. With Quintana steady and Milwaukee’s lineup deeper, the Brewers should finish the series strong, though Arizona won’t go quietly.

Score Prediction: Brewers 5, Diamondbacks 3
Pick: Milwaukee -1.5 (+125)
Total: Under 8.5 (-118) 

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