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Yankees vs Red Sox Betting Preview: AL East Rivalry Showdown

Yankees and Red Sox battle in Fenway with AL East playoff stakes high. Expert betting preview and score prediction.

(Photo by Getty Images) Lucas Giolito
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NY Yankees (81-65) at Boston (81-66)

  • When: Sep 12 2025, 7:10 PM
  • Where: Fenway Park, Boston
  • Where to watch: Apple TV+

Yankees vs. Red Sox – Game Betting Preview & Prediction

Moneyline: NY Yankees -120 
Spread: NY Yankees -1.5 (+141)
Total: 9.0

New York Yankees Betting Outlook

The Yankees (81-65) enter Fenway Park slightly favored at -120 on the moneyline, with the total set at 9.0 runs. After avoiding a sweep against Detroit with a 9-3 victory, New York leans on the strength of its rotation and Aaron Judge’s hot bat.

Judge went deep twice on Wednesday, tying Joe DiMaggio for fourth on the franchise’s all-time home run list. Cam Schlittler also gave the team six strong innings, continuing the Yankees’ stretch of steady starting pitching. In fact, New York starters have allowed two earned runs or fewer in 15 of their last 17 outings.

Friday’s task falls to right-hander Luis Gil (3-1, 3.31 ERA), who has been dominant in his career against Boston (1.27 ERA in four starts). If Gil can limit walks, as manager Aaron Boone emphasized, the Yankees have the clear edge in game one.

Boston Red Sox Betting Outlook

The Red Sox (81-66) are just half a game behind the Yankees, making this series pivotal in the AL East race. While they’ve missed the postseason in five of the past six years, the arrival of Alex Bregman has injected new fire into the rivalry.

Bregman’s first taste of Yankees-Red Sox action in August was memorable, he went 7-for-16 in Boston’s three-out-of-four series win in the Bronx. He and the Sox now look to build off that success as they return home, despite a disappointing walk-off loss to Oakland to close their road trip.

Boston turns to right-hander Lucas Giolito (10-3, 3.38 ERA), who has been inconsistent against New York (4.99 ERA in six career starts). His last outing saw him give up four runs in five innings, though he recently dominated Baltimore with eight shutout frames.

MLB Prediction & Betting Angle

The Yankees’ pitching depth and Judge’s form give them the upper hand. Boston has shown fight, but Giolito’s shaky history against New York is tough to ignore. New York’s rotation steadies the ship and Judge stays hot as the Yankees take the opener at Fenway.

Score Prediction: Yankees 5, Red Sox 3
Pick: NY Yankees (-120)
Total: Under 9.0 (-115) 

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