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Ducks vs Golden Knights Picks & Game 1 Prediction

NHL betting preview, odds, and picks for Vegas vs Anaheim.

(Photo by Getty Images) Jack Eichel
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Anaheim (0-0) at Vegas (0-0)

  • When: May 4 2026, 9:30 PM
  • Where: T-Mobile Arena, Las Vegas, NV, USA
  • TV: ESPN

Anaheim vs Vegas NHL Preview & Pick

Moneyline: Vegas -160 
Spread: Vegas -1.5 (+155)
Total: 6.5

Vegas Golden Knights Breakdown

The Vegas Golden Knights enter this second-round matchup as a -160 favorite and the puckline -1.5 (+155) with the total set at 6.5, and the numbers reflect their long-term dominance in this rivalry. Vegas holds a 27-8-3 record all-time against Anaheim, including a strong home record, and they bring valuable playoff experience into this spot.

Jack Eichel continues to lead the offense, posting nine points in the opening round after a 90-point regular season. Vegas showed steady improvement defensively against Utah and that structure will be key against a faster Anaheim squad. The potential return of William Karlsson could also boost both special teams and two-way play.

From a betting perspective, Vegas offers reliability at home and a deeper, more experienced roster.

Anaheim Ducks Breakdown

The Anaheim Ducks arrive as a dangerous underdog after eliminating Edmonton in six games, and their current form cannot be ignored. They swept the regular-season series against Vegas, including two overtime wins, showing they can compete in tight situations.

Jackson LaCombe led the team with nine points in the first round and was strong defensively, while Cutter Gauthier added four goals after scoring 41 in the regular season. Leo Carlsson also contributed eight points in the opening series.

Anaheim’s biggest weapon has been its power play, converting at a high rate and creating consistent pressure. However, their youth and limited playoff experience could be tested in a road Game 1 environment.

Game Prediction

With a total of 6.5, this matchup leans toward moderate scoring, especially given Anaheim’s offensive upside and Vegas’ structured attack. While Anaheim has proven it can hang with Vegas, Game 1 at home favors the Golden Knights.

Vegas’ experience, depth, and home ice provide the edge, particularly in a series opener where composure often decides the outcome. Anaheim should remain competitive, but sustaining that level over 60 minutes on the road is a different challenge.

Score Prediction: Golden Knights 4, Ducks 2
Pick: Vegas -1.5 (+155)
Total: Under 6.5 (-120) 

2026 NBA Championship Odds

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