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Orioles vs Red Sox MLB Baseball Odds & Expert Parlay Picks

The division rival Baltimore and Boston are set to renew hostilities when they meet at Fenway Park.

(Photo by Getty Images) Lucas Giolito

Baltimore (16-32) at Boston (25-26)

  • When: May 22 2025, 6:45 PM
  • Where: Fenway Park, Boston
  • Where to watch: MASN

Orioles at Red Sox – Game Preview, Prediction and Player Props

Moneyline: Boston -130 | Total: 8.0

Baltimore Orioles Betting Breakdown

The O’s finally snapped an eight-game nosedive on Wednesday, outlasting Milwaukee 8-4 in extras to avoid a full-blown meltdown. Interim skipper Tony Mansolino earned his first win, but he deflected the credit to a clubhouse that’s been through the wringer. Adley Rutschman provided the spark blasting a clutch three-run shot in the 11th to seal the deal.

Still, the win didn’t come easy. Closer Felix Bautista struggled with command again, surrendering the tying run in the ninth inning, though his velocity looked promising. The bullpen remains shaky, which could be trouble in a tight game.

Lefty Cade Povich (1-3, 5.23 ERA) gets the start and has yet to solve Boston, posting a 5.28 ERA in three career appearances. He racks up strikeouts (19 in 15.1 IP vs BOS), but also gives up runs.

Player Prop (Orioles): Adley RutschmanOver 0.5 RBIs: Rutschman’s bat is heating up again, and with Boston’s starter scuffling, the switch-hitter could cash in.

Boston Red Sox Betting Breakdown

Boston comes limping into this series after whiffing 16 times in a 5-1 loss to the Mets on Wednesday. Ace Garrett Crochet was on a pitch count and didn’t factor into the decision. Now it’s Lucas Giolito’s turn and let’s just say “reliable” isn’t the word anyone’s using.

Giolito (1-1, 7.08 ERA) will toe the rubber for his sixth career start vs Baltimore. He’s been shaky all season, and while his record against the O’s is passable (3-2), the ERA tells the real story.

Player Prop (Red Sox): Rafael DeversOver 1.5 Total Bases: With Baltimore’s pitching still in flux, expect Devers to drive some action in this one.

Expert Prediction and Final Score:

The Red Sox offense has been inconsistent, but Rafael Devers remains a threat in the middle of the lineup. If they can get to Povich early, Boston should take advantage and pull out the win at home.

Final Score Prediction: Red Sox 5, Orioles 4
Lean: Boston ML (-130)
Total: 
Over 8.0 (-115)

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