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Red Sox vs Giants MLB Baseball Odds & Expert Picks

Boston and San Francisco will meet on the field at Oracle Park in a battle of interleague teams.

(Photo by Getty Images) Rafael Devers

Boston (39-37) at San Francisco (42-33)

  • When: Jun 20 2025, 10:15 PM
  • Where: Oracle Park, San Francisco
  • Where to watch: NBCS-BA

Red Sox vs Giants – Game Preview, Prediction and Player Props

Moneyline: San Francisco -125 | Total: 7.5

San Francisco Giants Outlook

The Giants welcome their newest acquisition, Rafael Devers, with a juicy subplot, facing the Red Sox just days after Boston shipped him out west. Devers is still settling in at DH, but manager Bob Melvin hinted at him possibly debuting at first base during this homestand to make room for Wilmer Flores at DH. Flores, by the way, delivered a clutch pinch-hit double Thursday to seal a 2-1 win over the Guardians.

Right-hander Hayden Birdsong (3-1, 2.79 ERA) gets the start and has been quietly excellent. He’s yet to allow more than three runs in a game since joining the rotation and should benefit from a Red Sox lineup that just lost its top power bat.

Top Giants Player Props:

Rafael Devers Over 1.5 Total Bases – Facing his former team? You better believe he’s swinging for extra bags.
Hayden Birdsong Over 5.5 Strikeouts – Boston’s offense is inconsistent on the road, and Birdsong has been efficient through five starts.

Boston Red Sox Outlook

Boston enters this series trying to steady themselves after trading away Devers. While they did take two of three from the Mariners, it’s hard to ignore the leadership and power void left behind. Still, young guns like Roman Anthony and Marcelo Mayer stepped up with homers in Seattle.

On the mound, Hunter Dobbins (4-1, 3.74 ERA) is hot, fresh off two wins against the Yankees where he allowed just three runs over 11 innings. He’s been getting run support, but can the new-look lineup back him again?

Top Red Sox Player Props:

Roman Anthony Over 0.5 Home Runs – The kid’s got power and confidence.
Hunter Dobbins Under 2.5 Earned Runs – He’s keeping hitters off-balance and comes in with momentum.

Betting Insight & Prediction

Backed by a consistent rotation and the extra spark Devers brings, San Francisco should grind out a close win in this reunion game. Boston will keep this game tight with Dobbins on the bump, but the absence of Devers and cross-country fatigue could hurt late. Close game, but the Devers revenge arc starts with a win for the orange and black.

Final Score Prediction: Giants 4, Red Sox 3
Lean: San Francisco ML (-125)
Total: 
Under 7.5 (-115) 

The Open 2025 Odds

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