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Brewers vs Giants MLB Baseball Odds & Expert Parlay Picks

Oracle Park has a contest on tap as Milwaukee and San Francisco will both be trying to pick up a win.

(Photo by Getty Images) Logan Webb

Milwaukee (13-11) at San Francisco (15-9)

  • When: Apr 23 2025, 9:45 PM
  • Where: Oracle Park, San Francisco
  • Where to watch: MLBN

MLB Expert Betting Breakdown – Brewers vs. Giants

Moneyline Favorite: San Francisco -139 | Total: 6.5

Milwaukee Brewers Outlook

The Brewers enter Wednesday’s showdown behind starter Freddy Peralta, who’s been electric early in 2025. Peralta carries a 2-1 record and stellar 1.91 ERA through five starts, having allowed no more than two runs in any outing. He’s been consistently dominant, including five shutout innings in his last start against the A’s. While Peralta hasn’t pitched at Oracle Park yet, he owns a solid 3.18 ERA in four career outings against the Giants.

With Peralta 18 strikeouts away from reaching 1,000 career Ks, look for him to chase milestones with high strikeout potential tonight. His command and whiff rates make him a prime candidate for a 7+ strikeout prop. The Brewers’ offense came alive in a big way during Tuesday’s 11-3 rout, offering some positive momentum after a quiet series opener.

Key Prediction:

Freddy Peralta Over 6.5 Strikeouts
Milwaukee Brewers Team Total Under 2.5 Runs (+110)

San Francisco Giants Outlook

Logan Webb counters for the Giants and remains a model of reliability, posting a 2.40 ERA with 28 strikeouts in 30 innings this season. He’s been lights-out in his last two outings, throwing 13 shutout innings with 22 Ks combined. Webb’s personal win-loss record doesn’t reflect his effectiveness, but San Francisco is unbeaten this season when scoring at least once during his starts.

Webb owns a perfect 2-0 record against the Brewers, supported by a strong 2.61 ERA over five matchups. His consistency makes him a good pick for a 6+ strikeouts prop and possibly a quality start if his defense doesn’t let him down again like they did in Tuesday’s defensive collapse.

Key Prediction:

Logan Webb Over 5.5 Strikeouts
San Francisco to Score First (+115)

Game Prediction & Betting Angle

This one sets up to be a pitcher’s duel with two strikeout-heavy arms who’ve both opened 2025 in sharp form. The public may be tempted by Milwaukee’s big Tuesday performance, but Webb’s track record and the Giants’ 3-0 record when scoring for him make this a dangerous spot.

Expect a bounce-back defensive effort and a lower-scoring, grind-it-out kind of game.

Best Bet: Under 6.5 (-115)
Lean: Giants ML (-139)
Final Score Prediction: Giants 3, Brewers 2

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